Goal
Gut health
The one goal where an oral route is a strength rather than a compromise.
Gut health here means intestinal barrier function and mucosal inflammation — the leaky-gut idea, IBD-adjacent symptoms, irritation from NSAIDs or alcohol. It does not mean digestion or the microbiome, neither of which this dataset models. The structural fact that makes this page different is that a compound acting inside the gut lumen does not need to survive absorption into the bloodstream, which is why oral dosing is credible here and almost nowhere else on the site.
Three compounds sit at 5. BPC-157 has an extensive rodent record in gut healing models and is taken orally for exactly the local-action reason above, but controlled human data is essentially absent. KPV, the anti-inflammatory tripeptide tail of alpha-MSH, is supported by animal and cell-culture work only, mainly rodent colitis models and in-vitro work on NF-kB signaling. Larazotide is the outlier and worth understanding: a zonulin antagonist that ran randomized placebo-controlled trials in coeliac disease, including a phase 3 that was stopped for futility at interim analysis. It has the best evidence in the group, and that evidence is negative. LL-37 follows at 2.
Get a diagnosis before you get a protocol. Coeliac disease, inflammatory bowel disease, H. pylori and SIBO all have real tests and real treatments, and none of those treatments are on this page; months of self-treatment is how a treatable condition becomes a complicated one. If you are addressing symptoms while that is in progress, the oral route is the lower-exposure starting point, and food triggers and NSAID use are worth removing first because they cost nothing to test.
How to read this
Match — how squarely it aims here
The weight the dataset gives this compound for this goal, 1 to 5. It describes intent and mechanism, not benefit, and not direction: a 5 means the compound acts hard on the system in question.
5/5Match strength 5 of 5primary useEvidence — whether anyone has shown it
Read from the compound’s evidence note and handling grade, for the compound as a whole rather than for this goal alone. A 5/5 match on animal data is a hypothesis, not a result.
- Human trialsRandomized or controlled human trials exist, or the compound holds a regulatory approval somewhere. Trials existing is not the same as trials succeeding — some of these were negative.
- Some human dataPublished human work exists but is small, early-phase, acute, or from a single group that nobody has replicated.
- Animal data onlyThe case rests on rodent and cell work. Doses shown are extrapolated, not established in people.
- Anecdotal onlyNo published trial record of any kind. Every number comes from vendor packaging and community practice.
4 compounds, strongest match first
Ranked for gut health
Match 5/5 · Primary use
3
Named stacks
Protocols built around this goal
Not sure this is your goal
Most people arrive wanting two or three of these at once, and the honest answer is usually to pick one and run it properly. The quiz weighs your goals against your experience, the routes you will tolerate and your contraindications, then shows its reasoning rather than just a name.
Take the quizOther goals
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.