Metabolic
Tesofensine
An oral triple monoamine (noradrenaline, dopamine, serotonin) reuptake inhibitor, not a peptide.
Also known as NS2330 · Obesitas
At a glance
Dose summary
Form
Nothing to reconstitute
Tesofensine is taken by mouth, not injected, so there is no vial, no diluent and no draw volume. The typical dose is 500 mcg per administration — that is the number on the capsule or tablet, and the reconstitution calculator deliberately excludes this compound.
Mechanism & evidence
What it is, and what is known
An oral triple monoamine (noradrenaline, dopamine, serotonin) reuptake inhibitor, not a peptide. A 24-week randomized phase 2 obesity trial tested 0.25, 0.5 and 1.0 mg daily; 0.5 mg is the dose carried forward and the strength approved in Mexico. It is NOT FDA or EMA approved. The 1.0 mg arm produced clearly more cardiovascular and psychiatric adverse effects, so the upper end of this range is documented but not recommended.
Values here are capsule strengths in mg, not vial sizes, and the reconstitution fields do not apply to an oral drug.
The caveat
A 24-week randomized phase 2 in obesity; approved in Mexico, not by the FDA or EMA. The 1 mg arm produced clearly more cardiovascular and psychiatric adverse effects.Tolerability
Reported side effects
- Insomnia, especially when taken late in the day
- Dry mouth
- Raised heart rate and blood pressure, dose-dependent and pronounced above 0.5 mg
- Agitation, anxiety or mood change
- Nausea and constipation
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, dry and dark. The figures above are shelf-life conventions, not stability testing on the product you bought.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.