GH secretagogue
Sermorelin
Synthetic analogue of the first 29 amino acids of GHRH.
Also known as GRF 1-29 · Sermorelin acetate · Geref
At a glance
Dose summary
No regulator and no trial set these numbers. They describe what people actually do, recorded so you can see the range rather than guess at it — which is not the same thing as a recommendation.
Reconstitution
What to draw, at the usual vial
A 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.50 mg/mL. A typical 300 mcg dose is 0.120 mL — pull the plunger to 12 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 5 mg | 2 mL | 2.50 mg/mL | 0.120 mL | 12 units | 16 |
| 10 mg | 2 mL | 5.00 mg/mL | 0.060 mL | 6 units | 33 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
Synthetic analogue of the first 29 amino acids of GHRH. Previously approved in the US as Geref for paediatric GH deficiency and used as a diagnostic agent, then withdrawn from the market for commercial reasons. Because it works through the pituitary it preserves pulsatile GH release, but modern adult data is thin and most anti-ageing dosing is extrapolated from that older clinical use.
The caveat
Approved in the US as Geref, then withdrawn for commercial reasons. Modern adult data is thin and anti-ageing dosing is extrapolated from that older paediatric use.Tolerability
Reported side effects
- Injection site redness, swelling or itching
- Flushing shortly after dosing
- Headache or transient dizziness
- Water retention and tingling in the hands
- Vivid dreams or drowsiness when dosed pre-bed
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Active, suspected or recently treated malignancy
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.