Other
MGF (Mechano Growth Factor)
MGF is IGF-1Ec, a splice variant of IGF-1 produced locally in muscle after mechanical loading or damage; what is sold as MGF is usually the 24-amino-acid C-terminal E-domain peptide.
Also known as Mechano Growth Factor · IGF-1Ec · IGF-1 splice variant · PEG-MGF
ANIMAL DATA ONLY
The evidence is animal and cell-culture work. There are no controlled human dosing trials, so every number below is convention rather than a result.
The underlying biology is genuine; injecting the peptide is a different proposition and has no controlled human dosing trials.
At a glance
Dose summary
No reliable human half-life has been published for MGF (Mechano Growth Factor), so none is listed rather than guessed at.
No regulator and no trial set these numbers. They describe what people actually do, recorded so you can see the range rather than guess at it — which is not the same thing as a recommendation.
Reconstitution
What to draw, at the usual vial
A 10 mg vial reconstituted with 2 mL of bacteriostatic water gives 5.00 mg/mL. A typical 200 mcg dose is 0.040 mL — pull the plunger to 4 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 10 mg | 2 mL | 5.00 mg/mL | 0.040 mL | 4 units | 50 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
MGF is IGF-1Ec, a splice variant of IGF-1 produced locally in muscle after mechanical loading or damage; what is sold as MGF is usually the 24-amino-acid C-terminal E-domain peptide. Like IGF-1 LR3 it is a growth factor acting on local tissue, NOT a growth hormone secretagogue — it does not stimulate the pituitary at all, which is why it is classed here as "other" rather than alongside ipamorelin or GHRP-2. The underlying biology (satellite cell activation and proliferation after loading) is genuine and studied in cell and animal models, but injecting the peptide is a different proposition from expressing it locally in loaded muscle: there are no controlled human dosing trials, and this is a bodybuilding-practice compound rather than a medicine.
Native MGF has a very short circulating life, measured in minutes, which is the rationale behind the pegylated PEG-MGF version sold as a longer-acting alternative; neither has usable human pharmacokinetics, so no half-life is listed. The 100-500 mcg per dose figures, the habit of injecting near the trained muscle, and the post-workout timing all come from forum practice, not from data.
Tolerability
Reported side effects
- Feeds into IGF-1 receptor signaling, so an active or suspected malignancy is a substantive contraindication rather than a formality
- Injection site soreness, swelling or a localised pump-like fullness
- Occasional headache or light-headedness after dosing
- Unknown long-term profile — there is no human safety data to draw on at all
- Unmodified MGF is cleared from the blood within minutes, so much of what is reported as an effect from subcutaneous dosing is hard to attribute
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Active, suspected or recently treated malignancy
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.