Metabolic
Cagrilintide
Long-acting amylin analogue, not a GLP-1.
Also known as AM833 · Cagri
At a glance
Dose summary
Reconstitution
What to draw, at the usual vial
A 10 mg vial reconstituted with 2 mL of bacteriostatic water gives 5.00 mg/mL. A typical 2.4 mg dose is 0.480 mL — pull the plunger to 48 units on a U-100 syringe.
Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 5 mg | 2 mL | 2.50 mg/mL | 0.960 mL | 96 units | 2 |
| 10 mg | 2 mL | 5.00 mg/mL | 0.480 mL | 48 units | 4 |
The highlighted row is the one quoted above: the smallest listed vial that holds at least four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Titration
Step-up ladder
This compound is escalated rather than held flat. Each step is a fixed number of weeks before the next increase — the side effects cluster in the days after a step, not at the top of the ladder.
| Step | Weeks | Dose | Note |
|---|---|---|---|
| 1 | 1–4 | 300 mcg | starting dose |
| 2 | 5–8 | 600 mcg | — |
| 3 | 9–12 | 1.2 mg | — |
| 4 | 13–16 | 2.4 mg | — |
| 5 | 17–20 | 4.5 mg | trial maximum |
Full ladder: 20 weeks from the starting dose to the top step.
Mechanism & evidence
What it is, and what is known
Long-acting amylin analogue, not a GLP-1. Phase 2 randomized human trials dosed 0.3 to 4.5 mg once weekly with 4-week step-ups, and it is in phase 3 combined with semaglutide as CagriSema. It is investigational and NOT approved anywhere as a standalone product. Amylin analogues act on satiety through a different receptor to GLP-1, which is the rationale for the combination, but standalone long-term data does not yet exist.
The caveat
Phase 2 complete, phase 3 running as a combination. No standalone long-term data.Tolerability
Reported side effects
- Nausea, generally milder than with a GLP-1 at equivalent appetite suppression
- Constipation
- Injection site reactions
- Reduced appetite and early satiety
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Under 18
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.