Healing & repair
ARA-290
Unusually well studied for this category: cibinetide reached randomized placebo-controlled phase 2 trials in sarcoidosis-associated small fiber neuropathy and in type 2 diabetes, typically 2-4 mg subcutaneously once…
Also known as Cibinetide · Helix B Surface Peptide · pHBSP
At a glance
Dose summary
Reconstitution
What to draw, at the usual vial
A 5 mg vial reconstituted with 2 mL of bacteriostatic water gives 2.50 mg/mL. A typical 4 mg dose is 1.600 mL — pull the plunger to 160 units on a U-100 syringe.
That will not fit one syringe
160 units is more than a 1 mL U-100 barrel holds. At this vial and this diluent volume the typical dose has to be split across two draws, or the vial mixed with less water to concentrate it. Work the alternative out on the calculator before you mix anything.Same dose, other vial sizes
| Vial | Water | Concentration | Draw | Units | Doses |
|---|---|---|---|---|---|
| 2 mg | 2 mL | 1.00 mg/mL | — | — | under one dose |
| 5 mg | 2 mL | 2.50 mg/mL | 1.600 mL | 160 units | 1 |
The highlighted row is the one quoted above: the largest listed vial, because no size here holds four typical doses. Change any of it — a different vial, more or less water, a different dose — on the reconstitution calculator, which draws the syringe to true U-100 graduations.
Mechanism & evidence
What it is, and what is known
Unusually well studied for this category: cibinetide reached randomized placebo-controlled phase 2 trials in sarcoidosis-associated small fiber neuropathy and in type 2 diabetes, typically 2-4 mg subcutaneously once daily for 28 days. Results were mixed and it is not approved anywhere. It is an EPO-derived peptide engineered not to stimulate erythropoiesis, so it does not raise haematocrit. Plasma half-life is only a few minutes; the effect is receptor-mediated and outlasts the exposure.
The caveat
Randomized placebo-controlled phase 2 work, but the results were mixed.Tolerability
Reported side effects
- Injection site reaction
- Headache
- Transient fatigue
Hard stops
Do not use this if
- Pregnancy, possible pregnancy, or breastfeeding
- Active, suspected or recently treated malignancy
These are flags, not a screening. They do not replace a conversation with a clinician who knows your history.
Handling
Storage
Keep it cold, keep it dark, and label the vial with the date you mixed it. Discard anything cloudy or past the window above.
Combinations
Commonly stacked with
Stacking multiplies the side-effect surface and makes it impossible to tell which compound did what. Add one thing at a time.
References
Sources
Educational information only, not medical advice. Talk to a licensed clinician before starting, changing, or stopping anything.